Grouppe Kurosawa Natural Medicine Blog Archives

Sodium Selenite Reactivates Silent Anti-tumor Genes in Prostate Cancer

When we think of genetic factors which predispose people to developing cancer, we usually think of mutations in selective growth control genes. These mutations are irreversible. But what most people do not realize is that there is another group of genetic alterations which influence the development of cancer that are not mutations and ARE reversible. These genetic factors are considered epigenetic modifications of gene functioning.

Many genes, especially tumor suppressor genes, are inactivated when certain DNA sequences in these genes are hypermethylated. Gene methylation is a normal method by which gene activity is modulated. Unfortunately, DNA methyltransferases, the enzymes which transfer the methyl group to the gene sequences, are over expressed in almost all cancers. Prostate cancer harbors a very large number of methylated, therefore inactive, genes.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15657340&itool=pubmed_docsum

The reactivation of these genes by DNA methyltransferase inhibitors is a major area of scientific research.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17998812&itool=pubmed_docsum

The oncogene RAS, which exists in mutated form in 30-50% of ALL cancers and leukemias, is responsible for the over activation of the DNA methyltransferase genes, thereby stimulating the production of a large number of gene silencing methyltransferase enzymes. Those cancers that do not harbor mutations in the RAS gene have mutations in downstream RAS signaling pathways that also can contribute to DNA methyltransferase activity.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7744770&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7829490&itool=pubmed_docsum

When DNA methyltransferase genes are introduced into normal cells, these cells become transformed or cancerous. If DNA methyltransferase genes are "turned off" by chemical means, the DNA in these cancer cells becomes demethylated and the cells die of apoptosis. DNA methyltransferase enzymes are clearly fundamental for the cancer transformation process.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=7713905&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=8415627&itool=pubmed_docsum

A number of DNA methyltransferase inhibitors are in development. Unfortunately, some of these inhibitors have proven toxic to normal cells. Sodium selenite is a powerful inhibitor of DNA methyltransferases. The selenite molecule directly binds the methyltransferase enzyme and inhibits its activity. This inhibition has NOTHING to do with selenite's ability to induce oxidative stress. This means that selenite can induce apoptosis in cancer and leukemia cells regardless of their p53 status. This is very good news.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18676679&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=9600343&itool=pubmed_docsum

Sodium selenite remains a critical component of our cancer and leukemia treatment protocols. The dose is one milligram per day, or five 200 microgram pills over the course of a day. This dose of selenite is not toxic in humans.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Sodium Selenite is an Anti-Cancer Agent Especially for Prostate Cancer

Sodium selenite is a component of our general cancer treatment protocol. We use sodium selenite because it rapidly depletes glutathione from cancer cells. This leads to oxidative stress and cancer cell death.

http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/03/sodium-selenite.htm

The mitochondrial oxidative stress induced by sodium selenite can be inhibited by the mitochondrial enzyme MnSOD, manganese superoxide dismutase.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18379781&itool=pubmed_docsum

Interestingly, the synthesis of MnSOD can be inhibited by the active form of vitamin D.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17604335&itool=pubmed_docsum

Since we are all relatively deficient in vitamin D, it makes sense that sodium selenite supplements would be impaired in their ability to induce oxidative stress in the absence of this vitamin.

There is another problem. Selenite induced oxidative stress and cancer cell death is dependent on the expression of the tumor suppressor p53. This is the major tumor suppressor in the body.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16489034&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16891474&itool=pubmed_docsum

Unfortunately, 50% of all cancers harbor mutations in the p53 gene, thereby minimizing the ability of oxidative stress to induce apoptosis in cancer cells.

Selenite is also known to block the activation of the gene for the testosterone receptor. It accomplishes this task by inducing oxidative stress. Oxygen radicals, in turn, inhibit the activity of the genetic factor Sp1 which is responsible for the activation of the testosterone receptor gene. Again, in the absence of p53 activity this is not going to happen.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16928829&itool=pubmed_docsum

Selenite's ability to kill cancer and leukemia cells transcend its ability to reduce glutathione and induce oxidative stress. In the next essay, I will present some exciting evidence that selenite directly inhibits the methylation of DNA gene sequences and the modification of histones which inhibits the activation of important genes, such as those producing tumor suppressor factors. Selenite reactivates these dormant genes. Prostate cancer is known to have an over abundance of methylated genes.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

                                                                                                                                                                  

The Economy Hits Grouppe Kurosawa

Rumors of my death have been exaggerated. I haven't posted anything for some time because I have been preoccupied with making a living. I no longer have an income as a scientific consultant to law firms. That income stream dried up when the economy went bad. Presently I am trying to get more publicity for my little book on home made topical remedies for pain, hair loss and herpes infections. Since I have to carefully watch my savings, I no longer purchase scientific articles. The average scientific article costs $30.

The good news is that I am now shipping methyl jasmonate all over the world. The Israeli scientists who wrote the bulk of the culture dish MJ studies know about GK and our MJ studies. They are not happy about it. They have told people who contacted them that MJ has not been properly tested in humans and that the inhalation of MJ is probably illegal. What a crock! These are the same people who said that MJ is in the same chemical toxicity category as table salt. They have a patent on the use of MJ to treat cancer, but it is completely unenforceable. No Pharma company is going to touch MJ. It is not a patentable molecule and it could wipe out the cancer drug market. If GK does not test this molecules effectiveness with its volunteers, it is never going to happen.

I will be posting new essays in the next few days.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Why Methyl Jasmonate is a Stand Alone Treatment for Cancer and Leukemia

There is increasing evidence that methyl jasmonate, a plant stress hormone, may be the ultimate stand alone treatment for ALL cancers and leukemias. The original research on MJ as a treatment for cancer began in Israel, but now scientists in other countries, including the US and Japan, have begun their own research programs on the anti-cancer properties of this simple compound.

MJ is a simple compound that in crude form is used to prevent the infection of plants by bacteria. In pure form, it is used by cosmetics companies as a scent. Now we know that MJ is a viable treatment for cancer and different forms of leukemia. Eventually, the Israeli scientists who discovered the anti-cancer properties of MJ will receive the Nobel Prize.

The ultimate anti-cancer compound is toxic to cancer but not normal cells. Preferably there would be no side effects such as vomiting and hair loss. Also, it would be nice if this compound was relatively inexpensive and easy to administer. Naturally, this is all wishful thinking. No such compound exists.

Or does it?

We all know that damage to the outer mitochondrial membrane is a primary signal for programmed cell death. However, the initiation of apoptosis AKA programmed cell is a complicated process. It requires the activation of many genes and the inactivation of others. Genetic defects in key gene activity can block the initiation of apoptosis. For example, during periods of oxidative stress or DNA damage the universal tumor suppressor p53 is activated. This protein promotes programmed cell death, thereby inhibiting the development of cancers. Unfortunately, over 50% of all cancers harbor genetic defects in the p53 gene rendering it ineffective in promoting cancer cell death.

Methyl jasmonate selectively kills cancer cells by binding to their mitochondria membranes and inducing damage. This damage initiates apoptosis, BUT it bypasses the normal complicated biochemical steps involved classical programmed cell death. MJ induced cell death is direct. It does not depend on the activation of other genes or the p53 status of the cancer cell.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15753398&itool=pubmed_docsum

We now know why MJ is so effective in killing cancer and leukemia cells.

First, a small technical review is in order.

It is well established that cancer cells are capable of using aerobic glycolysis to promote their growth and survival. The average cancer cell uses a combination of both glycolysis and respiration in its metabolism. The high aerobic glycolysis metabolism is critically important for cancer cells because it produces a rapid source of ATP. In addition, the glycolytic pathway activates the pentose monophosphate shunt. This shunt provides compounds that regenerate glutathione, the major anti-oxidant in cells, while producing precursors for the biosynthesis of nucleic acid, phospholipids, fatty acids, cholesterol, and porphyrins. Clearly high levels of aerobic glycolysis are absolutely necessary for the growth and survival of cancer and leukemia cells.

Over the last few years it has become clear that the enzyme hexokinase 2 (HK2), the first step in the metabolism of glucose, is over expressed in cancer cells. This enzyme, in order to be active, MUST bind the outer membrane of the mitochondria. Recent reports have found that the docking protein for HK2 on the mitochondrial membrane is VDAC, voltage dependent anion channel. The presence of VDAC on the mitochondrial membrane, the overexpression of the HK2 enzyme and the binding of HK2 to VDAC are fundamental aspects of the Warburg Effect, the aerobic glycolytic metabolism of cancer cells.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17879147&itool=pubmed_docsum

VDAC is a very interesting protein. It is the most prevalent protein in the mitochondrial outer membrane. This pore protein transports ADP and inorganic phosphate into the mitochondria for the production of ATP, the energy source of all cells. It also transports ATP out of the mitochondria into the cytoplasm of the cell. If VDAC activity is inhibited, apoptosis occurs.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17135295&itool=pubmed_docsum

In order for HK2 to promote aerobic glycolysis, it is dependent on the VDAC mediated transport of ATP to the bound HK2 enzyme.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18704666&itool=pubmed_docsum

HK2 binds VDAC after it is phosphorylated by enzymes such as AKT. AKT is a known cell growth and survival factor for cancer cells.

The binding of HK2 to VDAC apparently stabilizes VDAC and prevents its inactivity. As long as VDAC remains active, apoptosis is prevented.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15574336&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=14701745&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18039843&itool=pubmed_docsum

A number of VDAC inhibitors are now known to induce apoptosis. But this is only part of the story.

The release of cytochrome C, normally bound to the inner mitochondrial membrane, initiates the complex biochemical pathways associated with apoptosis. When HK2 is dislodged from the VDAC complex, cytochrome C is released into the cytoplasm. However, this effect is probably indirect. The inner mitochondrial membrane contains a protein called the permeability transition pore (PTP). Disruption of the functioning of this pore causes depolarization, membrane swelling, and the release of cytochrome C from its membrane binding site.

Hexokinase 2 detachment from the VDAC complex promotes the inactivation of both the VDAC and PTP pore complexes. This results in an inhibition of ATP synthesis and the promotion of cell death by necrosis, apoptosis and autophagy.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18350175&itool=pubmed_docsum

VDAC is not simply a binding site for HK2. The binding of HK2 to VDAC stabilizes the pore complex and prevents apoptosis.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18308720&itool=pubmed_docsum

A few months ago a study was published showing that methyl jasmonate binds directly to hexokinase and detaches it from VDAC. This results in an inactivation of VDAC and glycolysis, while promoting mitochondrial membrane swelling, and the release of cytochrome C into the cytoplasm. Cellular death rapidly follows.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18469866&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18408762&itool=pubmed_docsum

In addition to promoting apoptosis, methyl jasmonate also promotes necrosis. MJ promoted necrosis occurs in at least two different ways. First, it damages the mitochondria and promotes ATP depletion. Second, it promotes the expression of the tumor necrosis factor receptor in the membrane of cancer cells. TNF is the single most potent anti-cancer immune hormone yet identified.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18690087&itool=pubmed_docsum

Methyl jasmonate is administered in two different ways.

As an aerosol MJ is added to distilled water in a small personal steamer such as that manufactured by Vicks. It is sold by Amazon.com and large drug stores. 2 grams (2 milliliters) of MJ is added to the surface of the water where it will float as a light oil. The steamer is turned to high and the steam/MJ is inhaled into the lung. Breathe through the mask for 15-20 minutes. This is done every six days. I see no reason why it could not be done more often.

Topically 10 grams of MJ is added to 4 ounces of 70% DMSO gel. http://www.herbalremedies.com sells the gel that we prefer. It is made by Clinic Service Company.

This gel is applied up the nose for the treatment of brain cancer and onto the scrotum for the treatment of prostate cancer. As a more general method of delivery, the gel is applied to the arm pits. The arm pit area contains a high concentration of lymph nodes and lymphatic fluid. This is an excellent portal of topical entry into the circulation. The hair follicles in the arm pits are literally holes in the skin where MJ can be intoduced into the body. But first the hair follicles must be thoroughly washed with a detergent shampoo like Selsen Blue. This shampoo cleans out the crap clogging the follicle shafts. The topical formulations can be applied daily, although I would be careful sticking too much MJ at once up the nose.

Methyl jasmonate is used by Grouppe Kurosawa for our skin cream SkinAlive(R). We will sell 10 grams to others in the US for $180 including priority mail shipping. The total cost is $200 for shipping to Europe. Shipping costs vary for other parts of the world.

Payment is made by PayPal to smartin@grouppekurosawa.net.

It is my opinion that methyl jasmonate is the ONLY stand alone treatment for cancer and leukemia. Unlike other promising anti-cancer products which cannot be obtained by the general public, MJ is made by different manufacturers for sale to the cosmetics industry. It is a tad expensive, but a little goes a long way.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

A Successful Natural Treatment Protocol for Primary Liver Cancer

To all GK members:

Please refer to essay on Sept. 10, 2008 (A Natural Medicine Treatment for Primary Liver Cancer).

http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/09/a-natural-medicine-treatment-for-primary-liver-cancer.html

I was then and have been since then on the following protocol:
Glutamine 70g a day ( I weigh 190 lbs.)
Sodium Selenite 1 mg a day
Lithium Orotate  56.4mg a day
Policosanol 20mg a day
Vitamin B1  1 g + 500 mg a day
Vitamin  D3 10,000 IU a day
Vitamin A 1000,000 IU a day
Zinc Sulfate 50mg a day of elemental zinc dissolved in H2O
Flax Hull lingans , SDG 30/60 mg/g 10g a day
 And added:
Cimetidine 1g a day
Sulindac  600 mg a day
DCA 1 g a day dissolved in the l-Glutamine and water  (started this Sept. 7)
3 or 4 cups of double strength Black tea (two tea bags) ...Stopped at the end of Sept.
Because I have liver problems I did not take:

Mebendazole/ It was contraindicated for those with serious liver problems.

In August I had a CT scan: Impression: Progression in multifocal HCC. The contour of the liver is mildly lobulated suggesting cirrhosis.  All lesions had increased in size in comparison to CT scan done in May, 2008.

This was not good news. However I had no choice but to perservere. I continued the above protocol and continued the pharmaceutical Nexavar (a multiple  kinase inhibitor which is believed to control the growth of tumor cell and new blood vessels that give tumor its blood supply).

Got results from CT scan from 10/11/2008:
Impression: Liver is normal in size. There is interval decrease in size and number of hepatic lesions. The largest lesion decreased in size by 3.5 cm.

This was incredibly good news. This means downstaging with Primary Liver Cancer!! My oncologist said that I was in the 3% group. You don't see this everyday. The best they were hoping for really was stabilization.
My liver function panel was normal and enzymes elevated as usual because of Hep C and Cancer.

I don't know what is working but let me just say this, something is. The protocol obviously has caused me no ill effects and certainly has not interfered with the pharmeceutical Nexavar.

I have some worsening of portal vein thrombosis which is dangerous. But the oncologist said it is almost positively not cancer but a blood clot which is not uncommom for cancer patients. I am now on 4mg of Coumadin a day to try and resolve that.

I am ECSTATIC!!  I never in my dreams thought this could happen but still held out hope. Please read the Sept. 10 essay and feel free to comment and share your experience. I was supposed to have been dead last month. I am still on the right side of the grass and the cancer is dissapearing, albeit slowly, but it went in two months time, from Progression to Decrease in size and number.  WOW!!

Larry B. Houston, Texas

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

An Anti-oxidant Formula that Restores Dopamine Synthesis in Parkinson's Disease

An Open-Label Trial Evaluating a Dietary Food Supplement

for its Quality-of-Life Benefits for Parkinson’s Patients

Trial Background

A. The Early History

Approximately eight months ago, the Senior Research Scientist (Steven Evans) of the non-profit Therapeutics Research Institute (TRI) began an investigation into the etiology of Parkinson’s Disease (PD), using the published per-reviewed medical literature.  The goal was to identify possible dietary supplement strategies that might beneficially address quality of life issues for PD patients.  This effort led to a complex plan by Evans, and a participant was enlisted to try this regimen as a Case Study [Case Study #1 or CS#1].  This case study indicated that dietary supplements could in fact possibly favorably impact the Parkinson’s condition.

About the same time, a research colleague of Evans following the same medical research trail had devised a single detoxifying agent [Formula #12] and had independently undertaken to demonstrate its effectiveness as a quality of life adjunct for PD patients.  Evans recognized immediately that the far more complicated and difficult regimen he constructed for CS#1 was for all intent and purposes streamlined from more than a dozen supplements used by CS#1 to just one [Formula #12] and also offered improved impact.  Evans switched CS#1 to Formula #12 the past four months, documenting continued efficacy in terms of eliminating most symptoms to the largest degree.  At the same time, Evans’ colleague had been also doing a number of case studies, over a two year period, experiencing the overall same outcomes without exception with those who had PD diagnosed within approximately five years or so.  During this time, no side effects have been reported.  On the other hand, Formula #12 appears to have no impact on those with PD who have had the disease a much longer period of time (perhaps 10 years or more although we do not know just where this cross-over point is precisely).  Thus TRI wishes to undertake a mini-trial as a Proof of Concept, collecting data from approximately 30 people over a 21 day period, to assess the impact of this dietary supplement (Formula #12) on PD symptoms — for those who have not had PD diagnosed more than five years ago and who have some reduced quality of life.

B.  Formula #12

Formula #12 is a complex mixture of soy lecithin and alpha lipoic acid (along with a few other supporting ingredients such as lemon oil) .  What Formula #12 designers accomplished was to develop a cell membrane transporter (using the soy lecithin phospholipid) in concert with a way to bind it to the alpha lipoic acid as a well-known detoxifying agent.  Formula #12 can pass the blood-brain barrier and remove the build-up of hydrogen peroxide from the mitochondria of the cells — the heart(s) of the cells — so that the cells can once again function reasonably normally.  In the case of dopamine producing cells, this means the natural production again of dopamine for the PD patient, thereby aiding the patient’s physiology to operate to an improved degree.  From this internal production of dopamine accrues improved quality of life while presenting no side effects or adverse conditions.  At the present time, the Formula #12 designers have been producing limited quantities of Formula #12 and have been undertaking case studies over a two year period to elucidate the quality of life expectations of these case study participants.   Neither Evans nor TRI has any financial connections with Formula #12, its designers, nor with any economic outcomes of this research.

C.  Focus for this Trial

The Therapeutics Research Institute (TRI) wishes to identify approximately 30 individuals over the immediate short term who (1) have PD, (2) have not been diagnosed more than approximately five years ago with PD, and (3) who would be willing to take a food supplement documented as “GRAS” [”Generally Recognized As Safe” by governmental definition] for approximately three weeks.  The participants would be committed to taking the doses four times a day and filling out a short form on any impact it might have had on any symptoms related to PD that they experience. The overall study supervisor for this trial will be Steven Evans, President and Senior Research Scientist for the Therapeutics Research Institute.  A participant must meet the inclusion and exclusion criteria as provided in the Appendices.  They will receive Formula #12 without cost, may withdraw from the trial at any time, and will be monitored using a weekly Survey Form which they will check-off [a check list of their current status which may take about 5 minutes to complete per week].  They will have access to a trial hotline 24x7 which TRI will monitor and answer.  If any participant is a responder and wishes to continue on product while data is assessed, and/or if the trial is favorable and another trial is designed, such responders will be offered to remain on product without cost so long as product is available while any next steps are formulated.  If a larger trial goes forward, responders will be offered a preferential enrollment opportunity because there is an ethical obligation on our part that accrues to us because of the participant’s prior trial involvement.

During the trial, no participant is expected to terminate any medication (including any levadopa prescriptions) they are taking.  Since the goal is to determine whether Formula #12 can be a worthwhile adjunct to PD patients, it is sufficient to assess Formula #12 within an adjunct context. Each participant will initially fill out a short medical history and list of symptomatology.  Each week for three weeks they will check off a form [approximately 5 minutes] that summarizes any change in status of their symptomatology along with any perceived adverse effects or events. In the end, we wish to determine to what extent if any Formula #12 favorably impacted the quality of life of the PD participants.

D.  Background of TRI.  TRI was incorporated in 2001 as a non-profit corporation in Nebraska and is a 501(c)(3) public charity.  It publishes a bi-monthly Newsletter at no charge, highlighting peer-reviewed published medical literature identifying useful outcomes in alternative medicine.  Steven Evans is President and Senior Research Scientist for TRI as well as Editor-in-Chief of the newsletter issued by TRI.  He has been Vice President or Director of Research for a number of regional as well as national health care corporations, has been the Director of Instructional Science for the Creighton Schools of Medicine, Pharmacy, and Nursing for 14 years, and is the author or primary presenter of over a 100 articles, invited original work presentations, book chapters, books, technical papers, and/or a number of patents within the health care field.  He has been the designer and Trial Supervisor and Administrator for at least four other dietary supplement trials directly analogous to the one proposed.

E.  Taking Formula #12.  This product is a unique combination of soy lecithin, alpha lipoic acid, lemon oil and other identified binding agents.   It looks like peanut butter, comes in a squeeze tube a little like Velveeta cheese spread, and is taken four times a day on an empty stomach.  A small ball, about the size of a chick pea or small marble, is squeezed out and swallowed whole with some water.  It may be possible in the future to make a capsule, but this is not currently possible.  This food product does not need refrigeration.

F.  Selected Case Studies.    In our Case Study #1, this participant has been on Formula #12 for three months after following the more complicated original formulation for about three months.  Since he terminated his levadopa medications after about the initial two weeks, his continued excellent outcome likely indicates that  cellular detoxification permits restoration of dopamine production to an adequate extent.  In Case Study #2, this individual suffered from ever increasing PD disabilities although he had elected to take no medications prior to his trial participation.  He has been on Formula #12 for several months and has observed the nearly complete dissipation of his symptoms.  One is led to the probable conclusion that Formula #12 can restore quality of life to a PD patient.  In Case Study #3, the participant was taking traditional medication but failed to constrain numerous PD symptoms.  After the first week, symptoms were reduced, after the second week, symptoms were substantially abated, and by the third week, extraordinary symptom relief was obtained and has continued.  He is on his second month of participation.  Another several similar case studies are available.

 

Contact information http://www.formula12trial.weebly.com

 

Economic Turmoil, Psychological Stress and Cancer Growth

I have been reading articles in the newspaper about the extreme psychological stress suffered by people who are losing their homes and investment portfolios due to the current economic meltdown. People cannot sleep, their anxiety levels are at an all time high, and depression is becoming rampant. And suicides are increasing. A public employee in a nearby town was laid off after many years. He promptly went home and shot himself.

Psychotherapy at $150 an hour is not going to fix the problem. This economic disaster is worldwide and is not going away anytime soon. During this period of stress, both the incidence and rapidity of cancer deaths will increase. And there is nothing that the worldwide medical profession can do about it.

The following essay shows that stress hormones such as epinephrine (adrenaline) and norepinephrine promote the growth of tumors implanted in mice.

http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2006/07/chronic_stress_.html

Another stress hormone, hydrocortisone, is also known to inhibit the death of cancer cells.

Tumors develop in our bodies every minute of every day. Their growth is largely controlled by our immune systems. When the immune system is compromised by stress, these tumors are allowed to grow and spread. In addition, stress hormones DIRECTLY promote the growth and survival of cancers of all kinds.

If people cannot sleep due to anxiety, they will not be exposed to total darkness at night. This means their nightly secretion of melatonin will be inhibited. Recently, the World Health Organization refered to working the Night Shift as a carcinogen. Since light inhibits the secretion of melatonin, and melatonin is a known enhancer of immune responsiveness, the absence of secreted melatonin promotes the development and growth of cancer cells.

http://grouppekurosawa.typepad.com/grouppe_kurosawa_natural_/2008/01/the-night-shift.html

In these troubled times, take at least 3 mgs of melatonin pills at night. Also switch their hypertensive medicine to pindolol, a beta 1 and 2 blocker that also inhibits the secretion of norepinephrine from nerve endings. This drug is often prescribed off label as a treatment for anxiety.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

Methyl Jasmonate and a Stage Four Lung Cancer Diary

In June 2008 my wife, Yevette, was diagnosed with stage 4 lung cancer. The cancer had spread to her adrenal gland, liver and brain by the time it was discovered. She immediately started radiation treatments and was preparing to start chemotherapy. In July after her last radiation treatment she developed pneumonia and spent 7 days in ICU on a by-pap machine in the regional hospital. The Doctors said if her O2 levels continued to drop she would have to go on a ventilator and would not be able to come off it. They advised us to prepare for the worst because they didn’t think she could pull through. She pulled through and surprised us all and was sent home with an O2 concentrator. She was too weak to start the chemo and In August she started swelling to the point that fluid was oozing from her skin, her primary physician started her on Lasix for the swelling, her potassium levels dropped and she had to be readmitted to ICU to get her potassium back up.

While in ICU it was discovered she had fluid around her lung. She had 1100 ml of fluid drained from her lung. Again the doctors told us to prepare for the worst, again she pulled through. 10 days later (September) I took her to the local hospital to have more fluid drained from her lung, this time 1600 ml was removed. Later that night her heart went into arterial fibrillation. She was transported to the regional hospital and again she was put into ICU. This time the Dr's told us there was nothing more they could do and sent her back to the local hospital to be closer to her friends and family. After several days in the local hospital she was sent home under Hospice care. By this time she was so weak she could not stand without assistance and could only move a couple of steps to get to the bedside toilet.

September 16
 4 specialists, 1 ER admitting doctor and 1 general practitioner felt there was nothing else that could be done and that in a matter of days or hours she would die. What they didn’t realize is that neither she nor I were willing to give up that easily

September 18
I gave her the first treatment of Methyl Jasmonate using a Vick's Personal Steam Inhaler with 2 ml of methyl jasmonate (2 grams). She was not able to do the complete treatment because she was too weak to keep her head over the inhaler. Prior to the treatments she had very labored breathing, especially when she was sleeping and also had sleep apnea with 4 to 5 second pauses between breaths. This had been going on for over 2 years

September 19
I started noticing an improvement in her breathing, she still had the apnea but she was no longer struggling to breath. September 21 I noticed the swelling was reducing

September 22
I stopped giving her Lasix, the swelling was still reducing. September 24 I gave her the second treatment of MJ. She was still not able to complete the entire treatment. The swelling was still reducing and almost completely gone September 25 Her breathing is the best it has been in over 2 years and NO sleep apnea! The swelling is gone and she is getting stronger

September 29
I gave her the third treatment of MJ. She was able to do most of the treatment. She is still getting stronger

October 2
We went to see my wife’s primary doctor, He was very surprised to see that she had walked into his office (the two previous visits she was in a wheel chair). She had to use a walker but she made it under her own power. After listening to her breathing he said her lungs sounded much better. Her O2 saturation was checked while on 3 ml of oxygen and registered 100, the oxygen was removed and she was rechecked approximately 20 minutes later, her O2 saturation was 94. Her doctor told her that she no longer needed to be on oxygen all the time and she could use it when she felt short of breath. He wanted to know more about what we were doing. I told him we were using Methyl Jasmonate, he asked about the dosage and cost, when I told him he said “that’s cheaper than anything we can do”. He then said it looks like its helping and to keep him informed on her progress. She made the comment that she didn’t realize how sick she was the last time she was in ICU.

Her doctor said “yes, they sent you back here to die” (that was an eye opener for her). She still needs help standing but can walk. There is no more swelling, her breathing is good, her lung sounds are good (not normal yet but getting there), her strength is slowly returning and she is much more alert. We have no doubt that the MJ treatments are benefiting her Her doctor said that normally as a general practitioner he would not order further tests on someone with her diagnosis but he was curious as to her remarkable improvement and scheduled her an appointment for October 23 for blood work and X-rays.

October 6
I gave her the fourth treatment of MJ. She was able to do almost all of the treatment again. About half way through the treatment she said her vision got a little blurry. About 45 minutes after the treatment she said her vision was back to normal She is still slowly getting stronger, and can now occasionally get up off the bed by herself. She is only wearing the O2 about half the time now and it is down to 2 lpm. She went all night without the O2.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com

A Blog Member is Attempting to Shut Down the GK Website

This gentleman, a blog member, is going to attempt to shut down the GK website because he claims we owe him $33. He lives in Australia and suffers from melanoma. The emails speak for themselves. This is the kind of crap that Carole and I have to infrequently deal with. This is the mans last email. The email below was Caroles response to his daily email demand for "his" $33.

YOU SAID "we will not respond to any more emails from you on this subject"
 
Please read my emails to the professor again. Obviously you have not read them because you are failing to adress the relevant facts.
 
I do not like going around in circles having people ignore the facts and keep repeating things that are irrelevant.
 
FACT: The professor agreed to answer questions regarding immunolgy for one and refused to even attempt to answer them. Don't send me a statement of what is on your web site. Read it yourself if you like. What follows is "THE AGREEMENT" Either Google or go and get a book on Contracts and Law, the professor's second favorite subject. The professor's agreement to answer technical questions in addition to protocol relevant guidance was included. He refused to make any attempt. If he had made an attempt, even a poor quality one I would not have any grounds to have my money returned. Under law I would only be entitled to make a complaint. Again I do not like repeating facts and being ignored.
    Please read below from previous email.
 
    This was my question..."I have some technical questions
    spanning molecular, tumor and cell biology, bioinformatics
    as well as immunology. In     addition to the help with
    protocol etc, can you answer or try to answer them for
    me as part of the $100 consult?"
 
    This was your answer... "yes, I can answer your questions
    in a consult. "
 
FACT: The consult was cancelled by default by you when questions were refused on more than one occasion. That means you return my money for the unused part of the month. Anyone can see the justice and logic in that. It was not cancelled by me and your continued claims that I asked for you to do research is an attempt at deception. It's a simple matter of failing to deliver on an agreement.
 
FACT: There is no question of me canceling anything. I just want my money back because in retrospect it perceives to be appropriated by deception if it is not returned and the agreement between your professor and me appears to be a deception if I leave things be. $33.00 is an insignificant amount of money compared to "My Valuable" time. My problem is with people who do not deliver on agreements, try to deceive them and then try to confound and waste their time by ignoring the facts and insulting their intelligence with superfluous information.
 
FACT: There is no issue about doing research. I never assumed that is what was on offer. You people have brought this language into the matter as an attempt to confound the real issue and pull the wool over my eyes.
 
I am not stupid and unreasonable to think that for a mere $100 he would be writing long answers and doing reasearch. An immunologist would have answered those questions quickly and easily. If he is not a real professor of immunolgy and doesn't know his subject matter then this indeed is a big deception. On the other hand considering his hints about one hour consults and being charged $200 an hour it can also be a deception of another kind. Either way you look at it you certainly have an operation going up there.
 
Refusal to follow through on a promise constitutes a cancellation of an agreement or contract.
 
That occurred 8 days after sign up. The date of me taking action to recover my funds occurred ten days later but it was not before the end of the month. As a cancer patient I have other 'minor' matters to attend to besides trying to deal with people who attempt to deceive and steal from me. Actually I don't even care about the money. I had written it off when he refused to answer questions so I stopped asking them. My concern is the difference between right and wrong. I will not accept under any circumstances being deceived.
 
YOU SAID "I hope this puts an end to this issue as we will not respond to any more emails from you on this subject."
I SAY "You have a nerve. Go down that road and you will force me to take legal action that we will both regret. I am sick and tired of having to respond to YOUR emails when a simple apology and a full refund was in order many grueling emails ago. But the truth is revealed."
 
And stop insulting me with statements about providing a volunteer service. Although it may appear that way on the surface, it's entirely evident that you are running a purely "for profit" venture to exploit and deceive vulnerable cancer sufferers. There is some value in the information you provide but please stop the hypocrisy. You charge for what you do so don't insult people by calling it a volunteer service. The website is merely a front and a "front door" to a paid service. A few email exchanges like this is proof of that. It's a pity more people can't see it until they have been swindled. You need a dictionary to look up the word volunteer and again a law book to find that providing medical treatment information and charging them is illegal even with a disclaimer. I read recently that the FDA is running a new crackdown on people like you. I wonder if they are aware of you and your past record.
 
The matter has not ended and will not end until I receive my outstanding $33 (or $32.94 if you prefer) WITH INTEREST and a sincere apology.
 
You have 48 hours or my next very detailed correspondence will be with the FDA, PayPal, FBI, your web hosting company and the legal authorities in California. If that is not enough to "put an end to this issue" I shall take time to consider other as yet undetermined options.
 
Before I gave you the chance to end this amicably. Now you have been warned.
 
Be assured, refund or no refund the matter has NOW ended as far as polite reasoning goes.
 
Regards
Kaptan
----- Original Message -----
From: Carole Ann Dreier
To: kaptan
Sent: Sunday, October 05, 2008 1:59 PM
Subject: Consultation refund

Dear Mr. Onsoy,
Actually Steve's calculations for your refund were incorrect. You signed up on the 11th and requested a refund on the 29th. That's 18 days. If you prorate the $100 a month by a 30 day month, it comes to $3.33 a day. 18 days X $3.33 comes to $59.94. Steve rounded it up. So technically, your refund should have been $40.06. If you'd like the 6 cents, I'll be glad to refund it, but that's all you are owed.
 
Our website defines consultations as:
 
"1.17.2006
Individuals who require private individual consulting and treatment guidance on their medical condition can receive it for $100 a month. You can speak to Dr. Martin at any time, send him your current natural medicines protocols for evaluation, and cancel the consulting agreement whenever you wish."
 
Obviously you expected something different. Those who want his personal guidance on their protocols pay the consulting fee. It is not meant for him to do general research for you personally. You are a member of the Discussion Group/Blog and should know that there are many people out there who think Steve's time is valuable. This website is run on a volunteer basis and subscription fees, etc. handle the expenses. Rent or this country's economy has nothing to do with it.
 
I hope this puts an end to this issue as we will not respond to any more emails from you on this subject. Thank you.
 
Carole Dreier
webmaster, Grouppe Kurosawa

Methyl Jasmonate and Lung Cancer

I was contacted by a guy whose wife has stage four lung cancer. This is terminal and the oncologists won't treat her any more. He wanted methyl jasmonate for her treatment. I told him that MJ was her only hope since it could be inhaled directed into the lungs with a simple steam inhaler. He didn't have a PayPal account so his friend sent me the money. His friend, a woman named Georgie, is a real character. She told me that he knows that his wife is going to die, but he has to do something.
 
Well...the MJ worked and in a very short period of time.
 
This woman was confined to a wheel chair. She couldn't walk. Hell, she could barely breathe. She had such poor lung capacity that in the beginning she couldn't finish the weekly MJ/steam treatments.
 
A few days ago she visited her primary physician. With the help of a walker, she walked into his office under her own power. No wheel chair. He couldn't believe it. Her energy level is returning, she is more alert, and her lung functioning is almost back to normal. There is no question that MJ is inducing necrosis in her massive lung tumors. Otherwise, there is NO way that she could rebound this quickly. Programed cell death is a very slow process, but necrosis is immediate.
 
And they want to go on the record with their MJ treatments. They want the world to know that maybe, just maybe, lung cancer can be defeated with a simple compound like inhaled methyl jasmonate.  
 
And that's pretty cool. 

After she regains her strength and lung capacity back, maybe they can get a PET or CAT scan to positively document the reduction in tumor load. That would be incredible.

In the last few weeks, I have discussed the importance of targeting cancer stem cells in the treatment of cancer and leukemias. These cells are resistant to programmed cell death induced by chemo drugs and radiation. BUT, and this is a critical point, NO cell is resistant to a reduction in ATP levels resulting in necrosis. Methyl jasmonate is the most powerful inhibitor of ATP synthesis (necrosis) yet identified.

We are getting closer and closer every day to developing simple effective treatments for the treatment of cancers and leukemias.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest

http://www.grouppekurosawa.com