Enhancing the Effectiveness of Methyl Jasmonate. Flax Lignans
The primary objective of any treatment protocol is to find compounds that enhance each others effectiveness. This is an extremely difficult proposition, especially if you are dealing with natural medicines.
We have published extensively on the potent anti-cancer and anti-leukemia properties of methyl jasmonate, a plant defense hormone. However, like any natural medicine the effectiveness of MJ or any other product can be improved upon if you can find a synergistic or enhancing companion product. There isn't a product in the world that doesn't have some kind of therapeutic weakness.
In the following study, the PI3K/AKT signaling pathway was found to reduce the effectiveness of MJ. This is not surprising since AKT promotes aerobic glycolysis, a major metabolism of cancer cells, while blocking programmed cell death. This study uses the artificial glucose molecule 2-deoxy-d-glucose as a glycolysis inhibitor. Unfortunately, in the body 2-deoxy-d-glucose is a potent poison. There are more effective ways to reduce AKT signaling without killing the patient.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18953440&itool=pubmed_docsum
Flax lignans, powerful inhibitors of cancer cell growth, block AKT activation and other pro-cancer signaling pathways.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17876055&itool=pubmed_docsum
As discussed in the previous essay on swine flu, the best commercial source of highly concentrated flax prelignans is available from
We have published extensively on the potent anti-cancer and anti-leukemia properties of methyl jasmonate, a plant defense hormone. However, like any natural medicine the effectiveness of MJ or any other product can be improved upon if you can find a synergistic or enhancing companion product. There isn't a product in the world that doesn't have some kind of therapeutic weakness.
In the following study, the PI3K/AKT signaling pathway was found to reduce the effectiveness of MJ. This is not surprising since AKT promotes aerobic glycolysis, a major metabolism of cancer cells, while blocking programmed cell death. This study uses the artificial glucose molecule 2-deoxy-d-glucose as a glycolysis inhibitor. Unfortunately, in the body 2-deoxy-d-glucose is a potent poison. There are more effective ways to reduce AKT signaling without killing the patient.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=18953440&itool=pubmed_docsum
Flax lignans, powerful inhibitors of cancer cell growth, block AKT activation and other pro-cancer signaling pathways.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17876055&itool=pubmed_docsum
As discussed in the previous essay on swine flu, the best commercial source of highly concentrated flax prelignans is available from
http://www.aidshivawareness.org/flaxhull.htm.
This is a non profit organization that uses flax lignans for the treatment of cancer and AIDS in Africa. It is operated by a minister. They are good people.
Flax lignans should significantly enhance the anti-cancer properties of methyl jasmonate.
Stay tuned...
Grouppe Kurosawa, Medicine in the Public Interest
http://www.grouppekurosawa.com
posted by Dr. Steve at 7:54 AM
2 Comments:
Here are some other good AKT inhibitors.
Quercetin:
http://carcin.oxfordjournals.org/cgi/content/full/28/10/2114
Wortmannin:
http://www3.interscience.wiley.com/journal/112570684/abstract?CRETRY=1&SRETRY=0
Wortmannin is hepatotoxic and quercetin is not very bioavailable taken orally. Another alternative is damarane sapogenin but it is expensive:
sapogenin.info
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