The Major Oncogene RAS and It's Inhibition by Quercetin

The RAS family of oncogenes/cell growth proteins play a major role in over 60% of all cancers. RAS mutations or overexpression of RAS molecules is very common in colorectal tumors, melanoma, prostate cancer, breast cancer and lung cancer. Neutralizing RAS is a VERY big priority for most cancer therapies.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=16098678&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=11886512&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=16039940&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15746962&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=15231670&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=16354319&itool=pubmed_docsum

So now you know about the importance of RAS. The importance of the RAS family of cell growth molecules became known in the 1980s when I was a graduate student at UC Berkeley. Since then, the number of scientific articles published on this topic has continued to explode.

Inhibiting the expression of mutated or over expressed RAS molecules has been a primary objective of those interested in cancer treatment therapies for a very long time. To my knowledge, no one has ever managed to "turn off" the RAS family of genes.

I was wrong. Five years ago, a paper was published in the International Journal of Cancer showing that quercetin, our yellow flavonoid friend from fruits and vegetables (apples, yellow onions, raspberries, broccoli, green and black tea, and leafy greens) inhibited the genetic expression of all three members of the RAS oncogene family, both in colon cancer cell lines and in primary tumors.

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&
dopt=Abstract&list_uids=10652438&itool=pubmed_docsum

Holy Shit, Batman!!! Who knew?

Quercetin is NOW a component of all our cancer and leukemia treatment protocols. Give me some time to work out the details.

It is definitely going to be a Great New Year in the natural medicines field.

Stay tuned...

Grouppe Kurosawa, Medicine in the Public Interest
(http://www.grouppekurosawa.com)